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By Anthony Koleske

Abl relatives Kinases in improvement and disorder presents an outline of the services of Abl relatives kinases in improvement and disorder. This new name discusses the biochemical, genetic, and mobile organic facts that elucidate the mobile roles for those kinases in those tactics.

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Salgia R, Uemura N , Okuda K et al. CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J Biol Chem 1995; 270(49):29145-29150. 32. Wertheim JA, Perera SA, Hammer DA et al. Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate C M L development. Blood 2003; 102(6):2220-2228. 33. McWhirter JR, W a n g JY. Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins. Mol Cell Biol 1991; 11(3):1553-1565.

The nuclear ABL is inactivated by its association with RB. Upon release from RB, either through RB phosphorylation or degradation, nuclear ABL can become activated by signals generated from damaged DNA or tumor necrosis factor (TNF) receptor. Activated nuclear ABL can stimulate cell death by transcription-dependent (through p73 and/or RNA polymerase II) mechanism. Activated nuclear ABL can exit to the cytoplasm and stimulate cell death by transcription-independent mechanism. BCR-ABL-transformed cells, supporting the nuclear requirement for activated ABL kinase in inducing cell death.

Oncogene 2 0 0 1 ; 20(29):3845-3856. 40. Feller SM, Knudsen B, Hanafusa H . c-Abl kinase regulates the protein binding activity of c-Crk. E M B O J 1994; 13(10):2341-2351. 4 1 . Van Etten RA, Jackson P, Baltimore D. T h e mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization. Cell 1989; 58(4):669-678. 42. Lewis JM, Baskaran R, Taagepera S et al. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic- nuclear transport.

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